cenobamate will lower the level or outcome of fentanyl transdermal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Maximize dose of CYP3A4 substrate, as necessary, when coadministered with cenobamate.fentanyl transdermal and imipramine both equally increase sedation. Prevent or Use Alternate Drug. Restric